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ZOL-induced depletion of isoprenoid can stimulate a feedback mechanism in the mevalonate pathway and enhance the hydroxymethylglutaryl-CoA reductase activity accordingly (Supplementary Figure S1).
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More specifically, we hypothesize that persistently activated Fus3p which in turn activates Bni1 [34] can stimulate a positive feedback loop involving the polarized synthesis and transport of mating pathway components [26].
The slower healing response of the older rats did not stimulate a negative-feedback increase in the mRNA expression of stimulatory cytokines.
Therefore, IRS-2 may promote tumor progression by stimulating a positive feedback loop to enhance IGF-1 signaling.
This phenotype presents a high proliferation rate, produces large amounts of extracellular matrix and inflammatory cytokines, stimulating a positive feedback of inflammatory cell recruitment and collagen deposition [ 2].
The stress system activated by the immune system thus stimulates a negative feedback mechanism that protects the organism from an excess of inflammatory proteins.
This suggests that the receipt of useful information in the form of a feedback report can stimulate an appetite for more information.
The results reported here suggest that longer term exposure of D-cells to gastrin and G-Gly also stimulates a further negative feedback loop by enhancing subsequent somatostatin release thus providing a means to restrain acid hypersecretion caused by hypergastrinaemia and control longer term acid secretion.
Adaptations were made by giving extra attention to providing positive feedback, stimulating a positive attitude toward physical activities, and gradually increasing the level of physical activity.
29 32 A conventional narrative might run thus: training in technical and non-technical interventions to improve patient safety combined with measurement and performance feedback stimulated a change in behaviour which resulted in a reduction in BSIs from CVCs.
Second mechanism is based on the fact that during autophagy the nutrients generated by degradation of cargo in the autolysosomes stimulate mTOR, representing a feedback regulatory loop.
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