Sentence examples for stimulant tolerance from inspiring English sources

Symptoms to diagnose stimulant dependence include the presence of physical and psychological damage, craving, reduced ability to control stimulant use, development of stimulant tolerance with increased dosage for stable stimulant effects, withdrawal symptoms in case of abstinence, and mentally focusing on stimulant use and continued use despite detrimental consequences of stimulant use.

But nicotine gum runs the same risk of any addictive stimulant: Dependence and tolerance leading to even more use.

Tolerance to stimulant laxatives is rare and occurs mainly in the patients with more severe slow transit constipation.

Patients with severe constipation and slow transit, who frequently develop tolerance to stimulant laxatives, are also eligible for prucalopride treatment.

While effective in patients without a history of SUD 17, this dose level could be insufficient for the SUD population and might explain the poor treatment effects seen in earlier clinical trials 9– 12. Evidence from brain imaging studies suggests that long-term drug use may down-regulate brain dopamine systems in chronic drug-dependent individuals 18, leading to increased tolerance to stimulants.

Regarding long-term effects, it is well known that repeated use of CNS stimulants can lead to either tolerance or sensitization [ 23, 24].

HAL did not block the development of tolerance to the locomotor stimulant effects of caffeine, but did impair the recovery from tolerance following withdrawal of caffeine.

Therefore, the present study was designed to determine the degree to which DA receptors mediate the development of tolerance to the locomotor stimulant effects of caffeine.

Caffeine is a stimulant, and stimulants stimulate you.

Several lines of evidence suggest that dysregulation of this tolerance to intestinal TLR-stimulants, or disruption of the epithelial barrier separating PAMPs from responsive underlying tissues, may contribute to the development or perpetuation of IBDs.

Taken together, the limited data suggest maintenance of treatment response to stimulants over 6 months—2 years, without developing tolerance of treatment effects [ 24– 29].