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While significant progress has been made in this area, candidate biomarkers still need validation in prospective clinical studies [ 91].
However, according to a meta-analysis conducted by Krogsbøll et al. in 2012 [ 3], general checkups do not decrease mortality and morbidity, suggesting that their effects still need validation.
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The producers guild award was a big win for "The Hurt Locker," an Iraq war drama that had already cleaned up several critics awards but still needed validation from Hollywood's inner circle.
In this context, how Sepsis-3 criteria would perform for sepsis detection, especially in countries with high mortality rates, still needs validation.
The capacity of the AMS scale as clinical utility and as outcome measure still needs validation.
Whether the results are suitable to children and adolescents in other areas still needs validation through multicentre studies.
The (improved) in vitro models still needs validation, most likely using animal data, clearly alternative approaches need to be developed for this (making use of available human data).
Detection methods for α-synuclein in CSF are currently under development, although it is not clear how CSF levels relate to histopathology data (Mollenhauer 2014) and still need further validation.
First results are promising, but still need further validation in endemic settings.
Although the currently available data are promising, these approaches are still in its early stage, and their diagnostic values still need further validation.
More advanced techniques, such as motor unit number index, Bayesian MUNE, and electrical impedance myography, are more accurate but still need further validation against neuropathological correlates [ 23– 25].
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