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However, methods based on MALDI-TOF/TOF for biomarkers discovery still need optimization, in particular to reduce analysis time and to evaluate their reproducibility for peak intensities measurement.
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However, the use of MALDI-TOF/TOF as an analytical tool in clinical research still needs optimization and evaluation [ 13].
In spite various harvesting and preparation techniques have been implemented to provide performing fat grafts, the outcome of AFT still needs optimization [ 3].
Hence, this method still needs optimization, especially in terms of supporting blood vessel and nerves for artificial tissue survival and function.
However, 3D organoid models still need further optimizations such as the size and density of cell aggregates and the treatment period of NPs as well as drug-conjugated NPs [50].
Many applications don't need optimization, though.
Despite the multi-objective docking problem (1) has been simplified with the method of centers and aggregate function, the objective function of problem (10) is still nonlinear and the design space is non-convex, which means we still need a powerful optimization tool to solve this problem.
Although a reduction in the friction coefficient to below 0.13 is still needed for optimization or commercialization of the CrSiN coated cylinder barrel for water hydraulics, much improved friction behavior up to 1600 rpm obtained in a tap water environment, without delamination or surface cracking of the coating.
Other researchers have investigated normalizing blood vessels to reverse hypoxia as a means of increasing sensitization of tumor to radiation, a promising approach but which still needs further optimization.
The design of CFETR cryostat has not been finalized and structural optimization still need to be proceeded based on the analysis results.
Therefore, to investigate the effect of various parameters such as photoanode properties, counter electrode, electrolyte and sensitization time of photoanode, which decide performance of cells based on Sb2Se3 still need further studies and optimization.
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