As shown in Figure 3, filopodia appeared to modulate their mechanical response by decreasing the duration of the collision when encountering a stiffer obstacle.
But they face stiff obstacles, including stress and fewer resources.
As Disney and other Western entertainment groups have discovered, gaining access to produce films or Web content in China or even to market imported products faces stiff obstacles.
However, none of them has been developed successfully as anti-AD drugs mainly because of deleterious side effects; the broad specificity of the MMP inhibitors must be a stiff obstacle for developing safe and effective drugs.
It is a shame you were not able to forecast sooner the collapse in our economy despite the abundant signs: an extreme dependency on construction and tourism, very low productivity, poor rankings in education on every international indicator, a stiff labour market, obstacles to starting a business, the end of the flood of money from Brussels, etc.
The propagation of the crack is impeded by the stiff particles that act as obstacles slowing down the advancing of the crack front, whereas the latter takes place in a localised shear yielding, with the formation of damaged zone due to crack diversion, particle fracture and debonding of the particle/matrix interface (Luyt et al. 2006).
It was one of a few obstacles on his way to victory, as Troicki offered stiff resistance all the way to the end.
Despite stiff political opposition when the acquisition was announced last summer, the changing landscape in Washington has removed those obstacles, and the Securities and Exchange Commission is expected to approve the deal within days.
After ascending to a high point known for its breathtaking 360-degree views and stiff winds, they turned to the tape of their five-hour conversation about business leaders who had shoved obstacles out of the way to achieve success.
