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The manufactured sensor was capable of identifying the magnitude and orientation of an applied shear force at 1 N. Detection of a stiff region was also successfully demonstrated.
By its structural nature, a clique constitutes a stiff region of the protein.
Cells migrate from the soft region of the substrate toward the stiff region.
The native-like state is mechanically inhomogeneous, where the cleavage site interfaces a stiff region and a locally unfolded and flexible region along the molecule.
The approach most commonly used by our subjects to find the abnormal area on the VHB was to run two fingers simultaneously up and down the paravertebral region exerting fairly constant force and searching for the bump that reflected the abnormally stiff region.
Similar(55)
Here we have tested plasticity using essentially two different stiffness values in the MSCs that migrated from soft to stiff regions of the gradient.
We confirm that cells are able to sense through the thin film by observation of focal adhesions being positioned on stiff regions.
The key idea is related to the concept of percolation on elastic networks where the bulk modulus of the network suddenly changes when the fibrotic stiff regions or the emphysematous holes become suddenly connected across the network.
In those cells migrating from soft to stiff regions however, phenotype is not completely determined by the stiff hydrogel as some cells retain expression of a neural marker.
Cliques are expected to have great significance in protein-protein or protein-ligand interactions, as they are stiff regions, therefore likely to be conserved throughout evolution.
Cells have been shown to be sensitive to variations in stiffness and spread towards the stiffer region [27]; therefore, the cell would elongate along these stiffened regions applying stronger tractions at the same time.
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