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Additionally, in sterile models of inflammation, TLR-4 has been shown to respond to DAMPs, such as high mobility group-B1 [ 54- 56].
We studied sterile models of shock (induced by intravenous TNF or LPS) and a septic CLP model in female C57Bl/6 mice.
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A plea for the economics profession to abandon sterile, model-driven neoclassical dogma and return to the old verities (Hayek as much as Keynes) of pluralism and human agency, it is a remarkable, perhaps game-changing contribution by three young Manchester graduates.
Radial head fracture with sterile model (b) Fig. 6 2D CT scan (a), 3D Volume rendering (b) 3D Printed Replica of an ankle fracture with sterile model on the surgical table for plate testing (c).
The growth of 16 species of mould on the sterile model samples, prepared on the W&C and Cz&D media, was initially evaluated to select the species which can deteriorate the model materials.
We can only speculate on this discrepancy, but these authors used a short-term, un-resuscitated, sterile model in spontaneously breathing mice, whereas we investigated resuscitated polymicrobial septic shock in anesthetized and mechanically ventilated animals.
This study indicates that brominated noscapine analogs have potent anti-inflammatory activity in septic and sterile inflammation models, in a dose-dependent and time-dependent manner.
Our results that CB2 receptor inactivation decreases mortality during CLP-induced bacterial (non-sterile) sepsis might seem contradictory to the observations in experimental allergic encephalomyelitis, allergic skin inflammation, and ischemia/reperfusion-induced inflammation in that CB2 receptor inactivation is injurious in these sterile inflammation models.
Sequential action of different GPCR agonists has also been demonstrated in sterile injury models.
Laboratory studies of hypercapnic acidosis to date have been in sterile, nonsepsis models of ALI and systemic organ injury [ 89].
An excellent experimental model to study post-operative AF/AFL is the canine sterile pericarditis model of Page et al. In this model, sterile pericarditis is created by epicardial application of sterile talcum.
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