Sentence examples for sterile immunity from inspiring English sources

The protective efficacy and induction of sterile immunity following immunization with RAS are major drives for development of vaccines the target the pre-erythrocytic stages.

Recent advances in transgenic technology afforded a means to assess the actual contribution of CSP in the acquisition of sterile immunity following immunization of mice with irradiated P. berghei sporozoites.

First, others and we have shown that immune responses induced by various formulations against CS can significantly reduce liver stage development and even confer sterile immunity in immunized animals [15] [18].

To monitor sterile immunity after single immunization two groups of BALB/cAnN mice were immunized with 5×104 Py uis4 sporozoites and challenged on either day 7 or day 14 with 1×104 wild type P.yoelli sporozoites.

In spite of a vigorous host immune response, sterile immunity is rarely achieved.

PROBLEM: It has long been considered that the acquisition and maintenance of sterile immunity obtained through immunization with attenuated malaria sporozoites required the presence of infected hepatocytes.

We assessed the contribution of various immune system effectors to the induction of sterile immunity resulting from s.c. immunization with γ-spz.

Overall, we found that immunization led to sterile immunity irrespective of the origin of the CS in the immunizing or challenge sporozoites.

These results indicated that when P. berghei IrrSpz were used for immunization, they induced sterile immunity independently of the P. berghei CS.

However, the actual contribution of skin-primed immune responses to sterile immunity could not be deduced from this study.

Sterile immunity was also obtained by s.c. immunization in Cd81−/− mice (C57BL/6), where productive hepatic infections do not occur, and in their normal controls.