The authors measured and compared respiratory responses of six healthy male volunteers during (1) a stepwise target-controlled infusion of remifentanil, (2) a stepwise target-controlled infusion of dexmedetomidine, and (3) a pseudonatural sleep session.
METHODS: This study was designed to compare the analgesic responses of six healthy male volunteers during stepwise target-controlled infusions of remifentanil and dexmedetomidine.
Also included were treatment algorithms specifying a stepwise target-led drug treatment regime to reduce hyperglycaemia, blood pressure, hyperlipidaemia and microalbuminuria.
The remainder of the intervention was based on the stepwise target-led regimen from the Steno-2 study [ 23] aimed at optimising hyperglycaemia, hypertension, dyslipidaemia and microalbuminuria.
Biosimilar development involves an iterative, stepwise, target-directed approach resulting in a product that is highly similar to the approved reference biologic.
In the intensive treatment arm, GPs were encouraged through guidelines, educational meetings, and audits with feedback to introduce a stepwise target-led drug treatment regime to reduce hyperglycaemia, hypertension and hyperlipidaemia [10] based on the STENO-2 study [15].
The intensification of diabetes management was achieved through the addition of a number of features to existing diabetes care [ 7, 11], alongside lifestyle advice concerning diet, physical activity and tobacco consumption, and a stepwise target-led drug treatment regime to reduce hyperglycaemia, blood pressure, hyperlipidaemia and microalbuminuria.
Therefore, controlling internalization and the pharmacokinetic profile by structural optimization of the fusion protein can enhance specific tumor uptake in stepwise targeting.
At the time the LCA chip did not yet include CEP290 variants, stepwise targeted mutation analysis was performed prior to sequencing of the total coding region.
These findings suggest that genomic instability dependent on chromosomal breakage events is not stochastic, but occurs in a stepwise fashion, targeting some chromosomes clearly more than others.
