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In this system, clinics and diagnostics would no longer be partitioned, according to a stepwise scheme, from other disciplines as basic science, information technologies, ethics and policies.
A forward stepwise scheme, as used in Lappalainen et al. (2013) to map standard eQTL, was used to discover independent examples of epistasis.
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Today we have a broad variety of such systems employing oligonucleotides, peptides, and small organic molecules as templates and autocatalytic [1 3], cross-catalytic [4], collectively autocatalytic and non-autonomous (stepwise) schemes of self-replication [5].
Open image in new window Figure 4 Stepwise selection scheme.
Figure 1 provides a stepwise diagnostic scheme for the side-locked headaches.
In order to probe either the concerted or stepwise mechanism, Scheme 1 is proposed for the oxidation of quinoline catalyzed by Qor.
To pyramid several new QTLs, stepwise crossing schemes can be designed, although such schemes can require many generations of breeding.
Retrosynthetically, cis-alkenyl bisaldehyde 5 can be derived from partial hydrogenation (Lindlar catalyst) of symmetric internal alkyne 6 and stepwise Wittig olefination (Scheme 1).
After the skin reaction has cleared, pirfenidone may be re-introduced with the slower stepwise re-escalation scheme.
A stepwise optimization strategy is proposed, including a specialized initialization scheme to robustly compute good initial solutions with a minimum of user interaction.
Despite apparent political commitments to UHC in most countries, actual implementation and action have been understandably slow or delayed, given the enormity of some of these challenges (e.g. integrating SHI schemes and stepwise recruitment to a unified UHC scheme in Indonesia).
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