Unlike the previously proposed model, our model is a steady-state kinetic model based on the stepwise process of translation initiation, from the global folding of transcribed mRNA to ribosome binding.
Sandberg and Bridge [ 25] proposed a scheme for the stepwise process of genetic changes leading to the full development of malignant mesothelioma.
During the stepwise process of tumorigenesis, cells acquire a series of somatic mutations that lead to the excessive cell growth and eventually lead to the development of cancer.
Other approaches such as RNAup (Mückstein et al., 2006), IntaRNA (Busch et al., 2008), inRNAs (Salari et al., 2010a) and bistaRNA (Poolsap et al., 2010) fall into the third group, which considers RNA RNA interaction as the stepwise process of individual intramolecular foldings and their hybridization.
The transgenic RIP1-Tag2 mouse is an orthotopic model of multistage carcinogenesis and believed to better reflect the stepwise process of tumor development via distinctive stages, than conventional subcutaneous models with injected tumor cells [19], [23].
The Rip1-Tag2 is an orthotopic model of multistage carcinogenesis, believed to better reflect the stepwise process of tumor development via distinctive stages, than conventional subcutaneous models with injected tumor cells.
The cen3tel cellular system [22], [23], derived from human telomerase immortalized fibroblasts, has allowed us to follow the stepwise process of cellular transformation, from normal fibroblasts up to tumorigenic cells with metastatic potential.
Furthermore, certain explanatory variables were dropped by the stepwise process of multivariate logistic regression as a consequence of collinearity with another explanatory variable already in the model.
Aberrations already detected in adenomas may be early events in the stepwise process of accumulating changes which may cause progression of adenoma to carcinoma.
