Sentence examples for stepwise process in which from inspiring English sources

Melanoma development has classically been described as a stepwise process in which mature melanocytes acquire increasing number of mutations in oncogenes or tumor suppressor genes leading to uncontrolled proliferation, acquisition of invasive properties and metastatic potential [1].

As necrosis is a stepwise process in which cells become progressively smaller and more permeable to PI, the three populations most likely correspond to intact cells (P1) and to cells undergoing early (P2) and late (P3) steps of the necrosis process.

These results suggest a stage-related stepwise process in which the gene methylation regulatory elements were sequentially affected during the carcinogenesis process.

In summary, we show that KT-MT attachments are established in a deterministic stepwise process in which CENP-E, MCAK and HEC1Ndc80-loop control temporally distinct steps.

The analysing procedure was inductive and followed a stepwise process in which all authors were involved, with the first author (MS) mainly responsible.

However, the implementation of a biomarker usually involves a stepwise process, in which results from initial studies need to be confirmed in larger studies in independent populations, ideally performed in experimental environments that more closely resemble the "real-world" use of the biomarker [ 3, 5].

Recent single molecule FRET experiments led to the model for branch migration as a stepwise stochastic process in which the branch migration hop is terminated by the folding of the junction.

After autophagosomes are formed, they undergo a stepwise maturation process in which they engulf organelles, fuse with lysosomes, and mature into autolysosomes with lysosomal enzymes [ 16].

The optimal fixed effects structure was attained by a stepwise deletion process, in which each term was removed separately and LRTs were performed between each of the reduced models and the fuller model.

The variable selection for the final multivariate model was done as a backwards stepwise elimination process in which variables with the highest p-values were sequentially removed in turn until all the remaining variables in the model had a p-value < 0.05.

The organization of the focus group discussion (FGD) was a stepwise process during which schools were randomly selected, asking the head teacher permission to set up a FGD in the school with either teachers or fathers.