Sentence examples for stepwise maturation from inspiring English sources

After autophagosomes are formed, they undergo a stepwise maturation process in which they engulf organelles, fuse with lysosomes, and mature into autolysosomes with lysosomal enzymes [ 16].

The production of intermediate progenitors from radial progenitors appears to require transcription factors important in the stepwise maturation of neurons from dividing progenitors.

Osteoblasts originate from MSC via a stepwise maturation process.

The pathway is regulated at several stages, including formation of the autophagosome and the stepwise maturation of the organelle, by vesicle fusion, into an acidic, degradative autolysosome.

The culminating production of myeloid and lymphoid cells involves a stepwise maturation of lineage-committed precursor cells and the concerted action of transcription factors, cell to cell interactions, growth factors, and cytokines that regulate the expression or silencing of differentiation genes [ 10, 11].

During this stepwise process of maturation, new neurons gradually establish their final connectivity and become stable components of the pre-existing tri-synaptic hippocampal circuitry.

In recent immunoelectron microscopy studies, Dunn has reported that autophagosomes originating from pre-existing ER acquire lysosomal markers in a stepwise fashion during maturation into autolysosomes.

Ribosome biogenesis in bacteria involves several different GTPases, which are proposed to act as 'molecular switches', regulating the stepwise assembly and maturation of RNA protein subcomplexes (reviewed in Culver, 2001; Karbstein, 2007; Connolly and Culver, 2009).

A stepwise approach to the development and maturation of a line of research (e.g., Gitlin, 2013; Whyte, Gordon, & Rothi, 2009) will increase the quality and likelihood of success of efficacy trials.

Beside single PTMs, proteins are often modified through a combination of post-translational hydrolytic cleavages and the addition of functional groups through a stepwise processes leading to protein maturation or activation.

Maturation of blood vessels is a stepwise transition from an actively growing vascular bed to a quiescent functional network [5].