Sentence examples for stepwise dose escalation from inspiring English sources

Our aim was to test whether stepwise dose escalation attenuated the first dose effect of Nexvax2 in celiac disease patients.

A stepwise dose escalation was performed in order to determine the in vivo maximum tolerated dose (MTD).

Cisplatin (CDDP -resistant head and neCDDP -resistantlls were establisheadby stepwise dose escandtioneckth cancer

CDDP-resistant KB cells, KB/CDDP T), were established by stepwise dose escalation with CDDP in our laboratory.

Therefore, we used two exposing procedures, namely intermittent high-dose exposure and stepwise dose escalation from 10 nM, which is higher than the IC50 of the parental cell lines and similar to the in vitro IC50 for EGFR with L858R/T790M mutations.

The second study conducted, study II, was an intra-patient stepwise dose-escalation study in eight patients.

On the basis of the observations that most laboratory changes were transient, not associated with clinical symptoms and occurred early after the start of treatment, an intra-patient stepwise dose-escalation study was conducted to determine whether these laboratory changes could be reduced.

The maximum tolerated dose was determined to be 0.5 mg per day; but when using stepwise intra-patient dose escalation, a dose of 1.0 mg per day was well tolerated.

We propose, therefore, that for antigen-SIT in both allergy and AID, a stepwise approach, with dose escalation activating T cells through increasing strength of signal to a higher maintenance dose, will induce tolerogenic IL-10-secreting cells, capable of suppressing the effector properties of their initiating population.

No dose escalation was planned, but the dose of ficlatuzumab and/or erlotinib could be decreased stepwise.

Thus, no further dose escalation was performed.