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The combination of uPAR expression in both tumor-associated stromal cells as well as neoplastic cells in three subgroups showed a stepwise correlation in the log rank analysis for both OS and DFS (p = 0.030 and p = 0.017).
Kaplan Meier survival curves, using tertiles (cutoff values <12.56; 12.56 21.28; >21.28 pg TGF- β1 mg−1 protein; Figure 4A) or quartiles (not shown), showed a stepwise correlation for active and total TGF- β1 levels with tumour-associated survival.
The union of the two sets of 68 genes were defined as seed genes and generated an additional 271 nodes out of more than 50,000 candidate features by the stepwise correlation based selection (SCBS) procedure, which include 177 gene expressions, 82 copy number variation sites, 11 methylation sites and one somatic mutation site at gene TP53.
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These seed genes are then fed into our proposed stepwise correlation-based selector (SCBS) to select other features.
In the second simulation, we compare the proposed stepwise correlation-based feature selector with other existing methods.
One innovation of this paper is a novel stepwise correlation-based selector (SCBS) that mimics the hierarchy of the BN for feature selection.
The seed genes were then fed into a stepwise correlation-based selector to identify 271 additional features including 177 genes, 82 copy number variation sites, 11 methylation sites and 1 somatic mutation (at gene TP53).
First, we demonstrated that the stepwise correlation-based selection approach is more effective than simple single-round selection method in identifying important features in the genetic/epigenetic pathways, particularly those that are indirectly associated with the underlying phenotype.
Finally, multivariate forward stepwise correlations were used to assess predictors of cartilage volume loss independently of potential confounders.
The present study shows a stepwise positive correlation between severity of spinal pain and pain and dysfunction in the jaw-face region.
The relationship between liver fluke and human behavior, health service unit, and environmental factors using statistic analysis by stepwise multiple correlation.
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