Sentence examples for stepwise alterations from inspiring English sources

The morphologic heterogeneity of human salivary gland tumors belies the traditional concept of tumor progression through stepwise alterations in multiple molecular and cellular pathways.

Global gene expression profiling is ideally suited for analysis of the complex multifactorial, interactive and stepwise alterations in gene expressions that characterise tumorigenesis (Perou et al, 1999; Ross et al, 2000).

Our RNA-Seq whole transcriptome experiments broadly extend these studies and provide for the first time a global view of the stepwise alterations occurring during disease progression in mice.

It would now appear that delayed ischemic neurological deterioration may result not only from major proximal arterial vasospasm, but in addition from CSD clusters that in particular contribute to delayed ischemia by causing subtle but noticeable stepwise alterations toward hypoxic tissue conditions.

In the second phase, for each of the locally-optimised reference parameter sets a one-dimensional sensitivity analysis was performed through stepwise alteration of each parameter across a 36-fold range of values, centred on its value in the reference parameter set.

In line with our experimental objective, the more interesting outcome of the stepwise alteration of the minimal promoter when modifying the 5'-UTR was the further reduction of background expression in the off-state, already obvious from shortening the CMV leader sequence in Ptet-T3 and Ptet-T4 (> 30-fold reduction when compared to Ptet-1).

Aside from the stepwise genetic alterations known to underlie cancer cell creation, the microenvironment is known to profoundly influence subsequent tumor development, morphology and metastasis.

These include successive alterations of chromosomally located genes by either homologous recombination or point mutations, resulting in a stepwise modification of the molecular targets, which first leads to reduced susceptibility and eventually to complete resistance (21, 22 ).

Indeed, an aCGH signal is a stepwise constant, and alterations may co-occur in different chromosomes at the same time.

During stepwise ThD, thermal alteration of minerals was monitored by measuring the low-field magnetic susceptibility of samples at each demagnetization step (the measurements were performed using a Bartington MS2 meter).

Unlike in the examples with progressive, stepwise ptiO2 response modification, rapid, drastic alterations from a biphasic to a monophasic ptiO2 decrease pattern may occur, if a 2nd CSD quickly emerges before the previous ptiO2 response has returned to pre-event baseline.