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Combined, these patterns suggest an evolutionary stepwise acquisition of the tripartite mammalian C-peptide molecule, with insulin-interaction being ancestral, various turn stabilizations apparently of intermediate emergence, and possible receptor-interaction the most recent addition.
The results of stepwise acquisition and demagnetization of ARM showed several patterns that possibly represent differences in the provenance of the sediments and different water depths.
Starting from initiating driver mutations, this model depicts the stepwise acquisition of different driver mutations (early, intermediate, late and speedy drivers) during cancer evolution.
The results of stepwise acquisition and progressive AF demagnetization of ARM (Fig. 3) showed several patterns related to the location of samples in the basin.
On pilot specimens from 40 sites, we carried out a stepwise acquisition of ARM up to 100 mT with a 0.1-mT biasing field and alternating field (AF) demagnetization of the ARM.
Transformation and development of metastasis require stepwise acquisition of aggressive characteristics.
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This is achieved through a series of stepwise acquisitions of key abilities, such as disrupting signaling pathways, inactivating control mechanisms like apoptosis and the immune response, gaining access to unlimited proliferating factors as well as acquiring mobility and the potential to colonize new tissues [ 32].
Thus, 'full-version' LjSYMRK regulates both RN and AM symbioses, whereas 'short-version' OsSYMRK regulates AM symbiosis only, suggesting that stepwise domain acquisition by SYMRK has contributed to the evolution of RN symbiosis (Markmann et al. 2008).
Melting curve analysis was done at 45°C to 90°C (temperature transition, 20°C/s) with stepwise fluorescence acquisition by real-time measurement of fluorescence directly in the clear glass capillary tubes.
This clonally reproducing pathogen rapidly evolves through stepwise mutational acquisition of new virulences [ 32, 33], and the resulting arms race between plant breeders and the pathogen is characterised by frequent and rapid resistance breakdowns [ 34].
Li, C. et al. TCR transgenic mice reveal stepwise, multi-site acquisition of the distinctive fat-Treg phenotype.
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