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This phase of his career included his important 1970 review on the colonisation of the land by plants, which integrated information from plant fossils of all kinds into an influential overview that showed the stepwise accumulation of the features, such as water-conducting tissues and leaves, that today characterise almost all land plants.
The stepwise accumulation of genetic alterations in oncogenes and tumor suppressor genes will transform a normal cell and finally leads to carcinogenesis (Farber, 1984).
Large genomic studies also correlate germline genetic alterations and epigenetic features with adverse outcomes, further strengthening the link between the risk of metastasis and a stepwise accumulation of driver molecular lesions.
MDR-TB comes about as a result of the stepwise accumulation mutations in drug-resistance conferring genes.
Instead, the dominant paradigm for how multidrug resistance arises invokes sequential monotherapy leading to the progressive (stepwise) accumulation of resistance mutations as follows.
It is important to note that the acquisition of fluoroquinolone resistance in Salmonella requires the stepwise accumulation of gyrA mutations or the overexpression of efflux pumps [31].
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The development of this malignancy rises from the stepwise accumulations of multiple genetic alterations, leading to the activation of oncogenes and/or the inactivation of tumor suppressor genes.
Stepwise-accumulation model.
survival time between high and low salinities corresponded with a result that the stepwise-accumulation model showed the best BIC, 61.4 (Table 2).
Such a difference in survival time corresponded with a result that the stepwise-accumulation model showed the best BIC, 90.7 (Table 2).
survival time between salinities corresponded with a result that the stepwise-accumulation model showed the best BIC, 26.3, among the six models (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com