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After these two steps, we construct the maps (g n ) and (h n ) on each of the trains using the following lemma, a special case of Lemma 17. Suppose that each map of the sequence (f n ) has linear part of the form (z,w)↦(a n z,b n w), with |b n |≤|a n |.

As a next step, we constructed AxCAhBMP2-F/RGD and AxCAhBMP2-F/wt carrying human bone morphogenetic protein 2 (BMP2).

As a first step, we constructed a cryogen-free NbTi superconducting magnet with a 360 mm room temperature bore, which generated 4.5 T at a magnet center.

In a subsequent step, we constructed another network, connecting human host proteins if they significantly shared directly interacting viral proteins (P<0.01).

As a first step, we constructed transcription units (TUs) based on locations of the sequences in the genome.

In the second step, we constructed the initial measurement models of KDS-Yin and KDS-Yang with the factors yielded by the EFA.

In our preprocessing step, we constructed a scale-free and modular network from the gene-expression data (see Methods for more detail) [ 9, 14].

In the first step, we constructed for each of the families we had identified multiple alignments of the protease, reverse transcriptase and integrase domains using Mafft version 5 [ 30].

In the third step, we constructed a training set of onion gene models using 2,000 of the complete genes generated by the second process, and we then ran Augustus using the training set.

In a second step, we constructed a signature capable of separating MMR-deficient tumours into sporadic MSI and HNPCC cases, and validated this by a mathematical cross-validation approach.

Thus, as a first step, we constructed a global carotenoid biosynthesis network that included all confirmed enzymatic reactions that occur among naturally occurring carotenoids (Additional file 1: Appendix S1).

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