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We adjusted the values of Φ in three steps using experimental data where available.
The complete tumor growth kinetics for control and treated groups are obtained by interpolation and extrapolation methods with different time steps, using experimental data of fibrosarcoma Sa-37.
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In this study, we reported that LM8 displayed several superior biological characteristics in all metastatic steps rather than just a single step, by assessing the details of the metastatic cascade in a step-by-step manner using experimental systems to mimic in vivo conditions.
Therefore, as the next step toward using experimental data, a water shell around the full-atom initial structure is modeled using the program Solvate from Helmut Grubmüller's group.
The adequacy of the model at each step was carefully assessed using experimental data drawn from the literature.
The work is based on a non-linear one-dimensional population balance model (1D-PBM), which was parameterized using experimental step test data generated at a continuous granulation pilot plant installed at the University of Queensland, Australia.
The two-step nitrification model was validated using experimental data obtained from nitrifying batch cultures with variable initial concentrations of benzene (0, 7, 10 and 20 mg benzene-C l−1) and from additional batch cultures designed to evaluate specifically the toxic effect of cell preexposure to benzene concentrations (from 0 to 50 mg C l−1).
Critical steps were investigated during method development using experimental design to achieve a reliable and rugged assay.
Using experimental data, two-step model equations have been fitted for the hydrogen absorption and desorption reactions.
In the first step, black-box models are identified offline using experimental data.
The method refines each building block using experimental data before an oligomeric complex is constructed and all steps are compared with experimental data.
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