Thus, determining the key steps regulating necrosis should provide insights into potential therapeutic strategies for improving outcome in these patients.
Our multi-parametric systems analysis confirms that Raf inactivation is one of the key steps regulating ERK responses to be either transient or sustained.
The genes under positive selection are not key metabolic control steps regulating flux through the glycolytic pathway.
Desaturation of 18 0-ACP to 18 0-ACP catolyzed by a stromal stearoyl-ACP desaturase is one of the key steps regulating unsaturated FA levels in the cell.
As will be evident, specific sRNAs control events in LPS biosynthesis from its early steps, regulating a balance between amounts of fatty acids (phospholipids) and LPS as well as incorporation of specific nonstoichiometric modifications in LPS.
We then performed a local sensitivity analysis on the model to gain insight into the relative importance of different kinetic steps regulating DNA-bound doxorubicin following liposomal delivery for the mouse and human models.
Rab35 functions at an early endosome, prior to the relatively slow recycling endosome step regulated by Rab11.
The team of researchers drew up a step-by-step, regulated action plan in case of a participant being identified as having active suicidal risk or having a serious mental illness.
Enzymatic studies of full-length IGF1R and IGF1R fragments further demonstrate no role for allostery in maintaining IGF1R activity once it is phosphorylated, indicating that the key step regulated by ligand binding is autophosphorylation.
