All of them were predicted to play roles in the autophagy process, including from the first step of induction to the last step of vesicle fusion with the vacuole/lysosome.
Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design.
These observations lead us to suggest that FGF is the major, but not the only, signal involved in the early steps of neural induction, and that other signals remain to be identified.
While Noggin (produced by the notochord in vivo) re-specifies the dorsal neuroepithelium into ventral fates, Dkk1 inhibits the early steps of NC induction, without altering the axial cell fates or general patterning [53].
An impaired EBV-specific T-cell response could constitute one of the first steps of lymphoma induction with immunosuppressive drug therapy.
21 This may justify a possible pathogenic role of the anti-LRP4 antibodies, at least during the first few steps of ALS induction.
It has been reported that some sphingolipid metabolites, such as ceramides and sphingosine, can play a crucial role in many steps of apoptosis induction as regulators of some Bcl2 family proteins, by increasing intracellular Ca2+ levels and inducing mitochondrial stress.
The complex that regulates the initial steps of autophagy induction in yeast comprises Atg1, Atg13 and Atg17-Atg29-Atg31 and its formation is negatively regulated by the major nutrient-sensing kinase TOR.
