Sentence examples for steps of endogenous from inspiring English sources

CYP17 controls two successive early steps of endogenous estrogen biosynthesis by converting pregnenolone and progesterone to precursors of androgen and estrogen.

The general steps for each of the staining procedures are similar comprising the consecutive steps of endogenous alkaline phosphatase or peroxidase inhibition using 0.2 N HCl or 0.5%H2O2O2 in methanol, respectively, followed by heat-induced epitope retrieval (HIER), blocking of slides to prevent aspecific antibody binding, and application of the appropriate antibodies and visualization methods.

Cytochrome P450 (CYP) enzymes are essential for most biotransformation steps of xenobiotics and endogenous molecules [ 1, 2].

As mentioned earlier, a key regulatory step in the generation of endogenous rhythms is PER protein phosphorylation by casein kinase, which ultimately results in PER degradation.

In hepatocytes, OCT1 accounts for the first step in the detoxification of endogenous and xenobiotic compounds, including many drugs, since it carries out uptake across the sinusoidal membrane.

These findings point to isoAsp7-A β(1 42) as an agent triggering the initial step of AD – oligomerization of endogenous A β. Oxidative stress has a significant role in the development of AD, leading to an increase in the major stress protein HSP70.

Thus proper stage of tissue collection, strict tissue storage conditions, efficient extraction and purification steps to obtain material free of endogenous host cell proteins/components are critical in achieving desired efficacy and safety of the therapeutic.

RESPOND, a phase II double blind study aiming to recruit 488 patients, is the first step toward exploring the use of endogenous protein C level as a biomarker to guide the administration (both dosage and duration) of DrotAA.

The C-GAG copolymer matrix scaffold was cut into blocks of 6×× 4 × 3 mm (72 mm) before implantation, and we designated an optimal degradation time of around 28 days, in step with the time course of endogenous neural stem cell (NSC) proliferation and differentiation [ 10].

The latter result suggests that the AEC step may contribute to some destabilization of endogenous αSyn multimers during our purification (compare left and right sides of blot in Figure 5C).

Generally, the targeted approaches for discovery of endogenous DAACPs include two steps: screening DAACP candidates in biological samples and then localizing d-amino acid residues.