Sentence examples for steps of disease from inspiring English sources
Importantly, all initial steps of disease progression were recapitulated, including the incorporation of the tumor cells into their physiological microenvironment, transition of radial to vertical growth, and establishment of highly vascularized, aggressive tumors with dermal involvement.
Each stage undergoes unique epigenetic changes at different steps of disease progression in esophageal adenocarcinoma, suggesting a step-wise loss of multiple protective barriers against CpG island hypermethylation.
Furthermore, in cancer, mortality is often related to distant metastases which rather occur as late steps of disease progression.
The two growth phases that this fungus displays, i.e., a yeast phase and mycelial phase, are thought to be involved in key steps of disease development.
The biological information conveyed by mesenchymal signatures must also be considered to clarify which role(s) they might play in the different steps of disease progression.
Further assessment will clarify steps of disease initiation and progression and will help to develop and test therapeutic strategies for treatment of human DCM and ARVC.
Together these data suggest that the block of differentiation and the enhancement of self-renewal in CML stem cells may be a critical step of disease progression.
This observation can be taken as an indication of a later step of disease progression, whereby altered cardiac wall compliance is compensated for in addition to Dsg2 malfunction.
Note that the selection of prioritized genes set { g1, ···, g k} here is addressed by fitting a threshold θ R in the step of disease gene prioritization.
Colonisation is also recognized as the first step of disease development [ 2]. S. pneumoniae major virulence factor is the capsular polysaccharide upon which S. pneumoniae classification is based.
In general, first step of disease mechanism research is the identification of full-length gene sequences, specifically coding sequences (CDS), using cDNA library or RACE experiments for the investigation of a specific disease.
