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In fact, estimating the initial properties of structures is one of the first steps of damage detection process when using both vibration-based technique and model updating method.
The damage process assessed in FE modelling also revealed three steps of damage accumulation in the 3D braided composite under bending fatigue: (i) sharp stress decline; (ii) smooth stress decline and (iii) complete damage.
In consequence, this test can be expected to be very sensitive when early steps of damage recognition are involved but not necessarily for haploinsufficiency of BRCA1.
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In the initial step of damage recognition by XPC HR23B we observe a protein induced change in DNA conformation.
We often perform gauze packing for the first step of damage control (damage control surgery).
Damage is recognized by RPA, XPA, and XPC, and the enzyme specificity is ensured by the kinetic proofreading function of TFIIH, which hydrolyzes ATP along several steps of the damage recognition pathway to discern damaged DNA.
The early steps of DNA damage recognition and signaling in mammalian cells are not yet fully understood.
There is also the concern that the fixation and DNA denaturation steps of FISH damage chromosome structure.
Cotton boll weevil larvae chew for ~48 h on flower tissues, representing the early steps of insect damage.
The nucleous, however, remained unaffected in the early steps of cell damage induced by either free or liposomal ALA PDT but later changes inducing necrotic cell death, include nuclear structure disruption.
Hence, it was possible to examine the damage process step by step from initiation of damage to final perforation.
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