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And the structure of tribulus-shaped nanoparticle was realized via two steps of aggregation, i.e., random and linear oriented aggregation.
We compare our results for exemplary scenarios differing in spatial and temporal scales and exemplary species belonging to different functional groups through several steps of aggregation.
The condensation of silica continues on the silica-surfactant seeds in the water phase, and further steps of aggregation and restructuring can simultaneously take place which in summary control the morphology and pore structure of the final product.
There is a significant overlap between the regions of the sequence found to be solvent-exposed from the present study and those previously identified to be critical in the rate-determining steps of aggregation from protein engineering approaches.
Polypeptide sequences might contain local regions with high aggregation propensity that can nucleate the early steps of aggregation [22], [23].
We used SPT to study the initial steps of aggregation.
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Hierarchical median (at each step of aggregation, the median of transformed indicator values was applied).
Hierarchical fuzzy AND (at each step of aggregation, the fuzzy AND rule [22] was applied; see also below).
The aggregation rules applied were: Hierarchical mean (see Tables S3 for the structure of aggregation), where at each step of aggregation, the transformed indicator values were averaged.
The three steps consist of aggregation, optimization, and control.
In this model (the toxic species being an intermediate in the aggregation process), some factors such as Hsp104 could help or prevent the toxicity by favoring one or several steps of the aggregation process.
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