The annotation of the genome was refined in a multi-step approach, including modern bioinformatic pipelines, transcriptome and proteome data.
To deal with these challenges, the British Medical Research Council has developed a framework for evaluating complex interventions [9] that suggests a multi-step approach including a development phase, feasibility/piloting, evaluation (preferably through a randomised controlled trial) and implementation.
Highly ultrathin mesoporous Co3O4 nanosheets have been successfully designed and constructed on nickel foam substrate via a facile two-step approach, including a hydrothermal technique without any surfactant and followed calcination of precursor.
In a five-step approach, including pre-screen, primary filtering of inhibitors, re-screen, secondary filtering of inhibitors and graphical inspection and final selection, CAVS leads to selection of specific STAT inhibitory compounds.
These processes usually use a two-step approach including the synthesis of nano powder and particles and their subsequent consolidation by hot isostatic pressing, shock compression, powder sintering, etc, or a one-step approach such as electrodeposition, devitrification of amorphous and severe plastic deformation.
Current detection and genotyping methods of genogroup (G) I and II noroviruses (NoVs) consist of a 2-step approach including detection of viral RNA by TaqMan realtime RT-PCR (RT-qPCR) followed by conventional RT-PCR and sequencing of partial regions of ORF1 or ORF2.
Therefore, a two-step approach including matrix sublimation and subsequent recrystallization was developed by Bouschen et al. (2010).
A step-by-step approach, including more than one research center, is needed to develop valid, robust, and widely accepted ECPs.
They suggest a multi-step approach, including a development phase, followed by feasibility/piloting, evaluation (preferably through a randomised controlled trial) and implementation.
Prognostic factors for breast cancer LRR were identified using a three-step approach, including a scoping literature review, expert consultation, and regression modelling.
