"Star Trek" transporters do not employ this sort of transmitter and receiver setup; instead, Kirk just steps onto a transporter pad and away he goes, rematerializing at his destination.
Consequently a model reduction procedure was set-up and could be applied successfully, indicating that the parameter identification difficulties are caused by non-identifiable transporter steps, displayed by low parameter sensitivities and high parameter errors and correlations, which were then reduced in the model.
The release of one sodium ion from the crystallographically determined sodium binding site Na2 had been identified as an initial step in the transport cycle which prepares the transporter for substrate translocation by stabilizing an inward-open conformation.
The role of OCT1 in the pharmacokinetics or even the pharmacodynamic of these drugs depends on several factors, such as the step in which the transporter is involved (uptake or efflux), the type of drug transported (e.g., antineoplastic), and the existence of interactions among OCT1 substrates.
The majority of released 5-HT is cleared into neighbouring epithelial cells that surround the EC cell via the 5-HT transporter (SERT, step 4).
On the one hand, transition-0 is more likely to be the rate-limiting step, so that the transporter would not switch freely between the Cout and Cin states, thus limiting incidental leakage.
Insulin-stimulated glucose transport requires not only the translocation of GLUT4 to the plasma membrane but also a second step known as intrinsic transporter activation at the plasma membrane [9].
Furthermore, the internal xylose catabolism pathway used in conjunction with heterologous or engineered xylose transporters can determine the level of flux control exhibited by the transport step [ 67].
Step 3: Liberate energy transporters from anti-development and xenophobic policies that prevent us from selling abundant, world-class energy to allies around the globe.
However, which ABA transporter fulfils which step can be only hypothesized from its location and transport direction.
