The ability to directly visualize and quantitate UPR activation is an important step towards gaining novel insights into physiological UPR and improving therapeutic strategies targeting UPR in vivo.
In this context, the analysis of epigenetic effects — especially on the level of DNA methylation — represents an important step towards gaining further insights into the cellular response to butyrate addition.
Functional identification of the causal gene(s) within a disease-associated locus is the first essential step towards gaining new biological insight and identifying potential therapeutic targets.
As a first step towards informing decisions based on this methodology, insight is needed in individual differences in risk of relapse and response to treatment, and how relapse prevention strategies may differentially target vulnerability for relapse.
Overall we have taken the first step towards a network-based exploration of spatial signalling (whose insights extend beyond intracellular signalling), and a systematic study of the role of global elements therein.
This study is a step towards comprehensive spatially-explicit forest C estimation and reporting, with insights relevant for practices implemented in Canada and elsewhere.
The work presented here is a step towards further understanding this fascinating biological phenomenon that may provide insights into many biological processes including cell growth, cell division, metabolism, and the logic of cell-cell communication within complex, intricate microbial communities.
An essential step towards better understanding of this enigmatic disease is to gain more insights into the (epi genetic defects and deregulated signaling pathways leading to NB onco-genesis.
In doing so, it opens many avenues of exploration that will provide more insight into the biology of this disease – an essential first step towards developing new therapies.
These have revealed new insights into Xi chromatin and epigenetic interactions, an important step towards understanding the process of silencing – and escape.
