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APP can be cleaved by an alternative α-secretase rather than β-secretase in the first step to circumvent the generation of pathological A β peptide.
The sample preparation pipeline that we present here consists of a DNA isolation method from yeast cells performed in 96-well plates yielding high-quality genomic DNA, a DNA fragmentation method performed in PCR tubes with a sonicating water bath, and a heat inactivation step to circumvent the cleanups.
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Mr. Bloomberg said he would take several steps to circumvent obstacles to his proposals posed by city labor unions.
But these findings went further, saying that Massey took systematic and premeditated steps to circumvent government inspections.
Delivering his 11th and penultimate State of the City address, Mr. Bloomberg said he would take several steps to circumvent obstacles to his proposals posed by labor unions.
The truth is that while Mr. Bush and the Republicans will be more than happy to accept a final Supreme Court ruling in their favor, they are already prepared to take extraordinary steps to circumvent a ruling that goes against them.
Campaigners had urged Obama to take much bolder steps to circumvent the National Rifle Association lobby in Congress and deal directly with what he has described as the "scourge of gun violence" across the US.
In SAC's defense, a person familiar with the firm pointed out that two of the employees charged with insider trading started their scheme before joining the fund and had admitted taking extraordinary steps to circumvent SAC's procedures while another was trading in his personal account.
As large firms could achieve higher scores because of greater disclosure opportunities due to the complexity of their organizational structures and the number of businesses they manage, we took several steps to circumvent this problem.
It involves sensing the world (knowing where you are, where you want to go and what obstacles lie in your path), formulating a plan (reasoning about how to move and navigate safely), and executing planned actions (taking steps to circumvent or traverse obstacles in order to safely reach the goal location).
c Minor: Minimal clinical significance, involving minimising risk, assessing risk and considering an alternative drug, taking steps to circumvent interaction risk and/or instituting a monitoring plan.
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