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Pyruvate kinase catalyzes a key step regulating glycolysis and pyruvate is a known allosteric regulator of a number of glycolytic enzymes including pyruvate kinase, activity of which is induced during hypoxia when glycolysis is the major source of ATP [ 33, 34].
Further analysis identified the ERK-dependent phosphorylation of Ser551 as a key step regulating the translocation of Gab1.
As the phosphorylation of Fli1 at threonine 312 is a critical step regulating Fli1 transcriptional activity, we initially looked at the effect of ET-1 on the phosphorylation levels of Fli1 at threonine 312.
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The rolled dice at every step regulates the generated output sequence, which is similar as the behavior that macro-state of HSR wireless link quality regulates the generation of micro-state.
Rab35 functions at an early endosome, prior to the relatively slow recycling endosome step regulated by Rab11.
Enzymatic studies of full-length IGF1R and IGF1R fragments further demonstrate no role for allostery in maintaining IGF1R activity once it is phosphorylated, indicating that the key step regulated by ligand binding is autophosphorylation.
Thus, determining the key steps regulating necrosis should provide insights into potential therapeutic strategies for improving outcome in these patients.
Our multi-parametric systems analysis confirms that Raf inactivation is one of the key steps regulating ERK responses to be either transient or sustained.
The genes under positive selection are not key metabolic control steps regulating flux through the glycolytic pathway.
Desaturation of 18 0-ACP to 18 0-ACP catolyzed by a stromal stearoyl-ACP desaturase is one of the key steps regulating unsaturated FA levels in the cell.
As will be evident, specific sRNAs control events in LPS biosynthesis from its early steps, regulating a balance between amounts of fatty acids (phospholipids) and LPS as well as incorporation of specific nonstoichiometric modifications in LPS.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com