The immunological events triggering the onset and progression of clinical manifestations are also complex and multi-step, including breach of tolerance in the adaptive immune system, amplification of autoimmunity through innate and adaptive immune system dysregulation, and end-organ damage.
Sensitivity to chemicals appears to be the consequence of a two-step process: loss of tolerance in susceptible persons following exposure to various toxicants, and subsequent triggering of symptoms by extremely small quantities of previously tolerated chemicals, drugs, foods, and food and drug combinations including caffeine and alcohol.
The trend is funny, absurd and also heartening -- a step in the direction of tolerance.
This method is proved to be very sensitive (the determination limits are 0.077 μg ml−1 for bovine serum albumen (BSA) and 0.074 μg ml−1 for human serum albumen (HSA)), rapid (<2 min), simple (one step) and tolerance of most interfering substances.
In a reflection of his moderate stances, the Human Rights Campaign, the nation's largest gay rights political organization, immediately greeted his selection today as "a positive step that sends a message of tolerance and inclusion".
At the same time, I am worried that the film falls into a trap Russell would have recognised: the paradox of moral equivalence, of seeking to extend the logic of tolerance a step too far.
The final step in MetDP involved considerations of tolerance and toxicity in order to place emphasis on drugs that have potential clinical relevance against leishmaniasis.
Agreeing upon some common rules of communication, such as what constitutes hate speech, would be an important step toward insuring that the values of tolerance and mutual respect — the values Obama spoke about at the U.N. — eventually prevail.
The most crucial step of QTL mapping for salt tolerance in rice is the evaluation of salt tolerance (Wang et al. 2011).
The role of the TLR signaling pathway, and genetic variation therein, in vaccine-induced immunity in humans has so far received little attention [18], although TLR-mediated activation of dendritic cells and B cells, induction of cytokine expression, and reversal of tolerance are crucial steps in the induction of immunity.
