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12 37 An important step of the systematic review process is to assess the risk of bias of individual studies.
The final step of the systematic literature review included only 19 full papers and 5 recent abstracts that had targeted therapy as a research focus.
Based on this initial step of the systematic review, we identified the subcollection of evaluations that assessed the economics of primary prevention interventions targeted at dietary intake, weight management, or physical activity.
Figure 1 presents the number of articles identified, the number of articles included and excluded, and the rationale for inclusion or exclusion for each step of the systematic search.
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Additionally, despite the use of strict methodology and double data extraction at all steps of the systematic review, there is always potential for subjectivity in the semi-qualitative assessment of the classifications.
Fig 1 summarizes the steps of the systematic review.
The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart detailing all the steps of the systematic review is provided in Figure 1.
Two independent reviewers were involved in all steps of the systematic process and discrepancies in screening documents and search hits for relevance were solved by discussion and consensus.
Our comprehensive approach to scanning the existing literature and use of agreement between both investigators at all steps of the systematic review process are certainly strong points of our approach.
In this research, as the first step for the systematic design of microdevices, a design problem of a plate-fin microdevice was focused on, and characteristics of flow pattern inside plate-fin microdevices were investigated by using computational fluid dynamics (CFD).
The gene in question was then turned "OFF" and the simulation was continued for 19 more millions of steps for the systematic mutants analysis or until steady-state was reached for the other analysis.
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