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This step of the methodological framework raises issues of confounding bias because not all factors that can confound these associations are measured and controlled or even known.
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Certain steps of the methodological approach employed in this research were similar to methods in previous publications.
Our prior study showed that insufficient confounder selection led to high false positive rates [ 31] and therefore we designed the two-step LASSO regression (step 1 of the proposed methodological framework) to select more associated confounders.
In order to reach the objectives of the first step of the RECORD study, we report the methodological approach and the results of the development and validation of different algorithms of classification for RA at different levels of the healthcare system, including primary care.
Figure 1 Schematic overview of the methodological steps in the analysis.
For a summary of the methodological steps, see Figure 2.
The purpose of this paper is to provide a roadmap of the methodological steps necessary to create such a scoring system.
In the second methodological step of the coarse radar the above mentioned distinction between the technology push and the demand pull perspective was eliminated as each newly-found topic was investigated under the ongoing monitoring process to discover whether it would satisfy both aspects of these complementary perspectives.
The methodologist supervises the systematic literature search and will co-chair all meetings and is in charge of the methodological aspects of the various steps of the project.
Table 3 shows the steps of the inclusion process: The methodological quality of the twelve included studies was then assessed by two meta-reviewers (ALF and PM) independently, with the Quality Assessment Checklist for Reviews [ 43, 44] (see Additional file 2).
Next, we codified the procedural steps for assessing the methodological orientation and features of selected studies.
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