The result of the two steps of module (i) is an uncurated annotation which is to be analysed and curated in module (ii) and (iii).
Each module can run on its own clock, where each step of the module coincides with a clock tick of the module's clock.
The computation is finished in one step of the module's clock.
The first interpretation keeps the view that a step of the module coincides with an instant, whereas in the second interpretation new instants are introduced by the refined clocks, but these instants are not visible to the outside.
The minimization procedure is the most computationally expensive step of the module construction, as it closely resembles the Steiner tree problem [ 37, 38].
These events would occur as follows: Step 1) duplication of module 1 to form a bimodular gene, Step 2) duplication of the bimodular gene (modules 1 and 2) to form a tetramodular gene (modules 1 4), and Step 3) duplication of modules 3 and 4 to form a hexamodular gene (modules 1 6) (Fig. 8A, 6A).
We are interested in steps of the module's base clock C0, which is not explicitly declared.
This analysis included several steps of functional module discovery and selection, as illustrated in Figure 8. First, GO annotation was utilized to choose gene sets, which are involved in DCM (or non-DCM) CePIN, with significant enrichment of functional categories in biological process ontology (P ≤ 0.05).
As a result of this evaluation it was decided to remove one activity from Module 3, increase by two weeks the wrap-up module duration, deliver tutors' performance feedback every two weeks instead of every module, and, lastly, the addition of new steps or integration of Module 2 external activities into the Moodle system.
The OP PK module is connected to the system model through an inhibitory link to the release step of the viral life module, while the AMT PK module is linked through the replication step.
