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To ask where the optimum between pedigree-depth minimization and fast reproduction lies, we defined a fitness value that captures the effects of delays in the reproductive schedule due to slow stem-cell cycling and of long-term mutational load stemming from replication-dependent mutations (the equation and details are given in " Methods").
These facets stem from the fact that PV are replication incompetent, recombinant viruses that can be engineered to contain one of several different reporter genes and a range of different RABV glycoproteins (G) protruding from their viral membrane.
We defined a fitness function that captures the effects of delays in the reproductive schedules due to slow germ-cell cycling and of long-term mutational load stemming from replication-dependent mutations.
This stems from the widely accepted notion that self-replication of biopolymers is essential for life's inception.
This switch may stem from the loss of just one or a few mitochondrion-specific DNA repair or replication genes.
"That stems from the manager himself.
Its upcoming woes stem from the fallout.
This stems from the colonialist era, correct?
The moves stems from the International Air Transport Association.
This stems from the top.
The problem stemmed from the wings.
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