Even though we do not yet know how pathogenesis ensues, one compelling mechanism is transcriptional misregulation stemming from alteration in histone acetylation.
Notably, most of the dominant alterations (e.g. G64A and Δ596-598) occurred independently in progenies stemming from the two initially infected plants, indicating their importance for viral fitness.
The choice of these parameters stems from the proposed structural alterations in variants M13V, M13V/K22M, and A7F relative to wt as described above.
The requirement to identify a method for isolation and growth of normal OSE and OC cells from human patients partially stems from the known genetic alterations in existing established cell lines, and the absence of animal models for epithelial OC [with the exception of aging chickens (1).
This would mean that the islet cells in pancreatic tissue are the tissue-specific stem cells in which cancer cells begin from the alteration in the oncogenes or tumour suppressor genes.
Prader-Willi Syndrome (PWS) is a rare congenital disease stemming from an alteration or the lack of expression of the paternal chromosome 15 in the locus 13-15q.
An increased NADH/NAD ratio also increases pyruvate by inhibiting pyruvate dehydrogenase, and hence its conversion into acetylcoenzyme A. Consequently, the increase in lactate production in an anaerobic setting is the result of an accumulation of pyruvate that is converted into lactate, which stems from alterations in the redox potential.
It is thus conceivable that a number of neuropsychiatric disorders may stem from an alteration or disruption in the balance of excitation vs. inhibition in the cortical circuitry.
This difficulty stems from the many confounding factors in these patients, and from the lack of data on functional or structural alterations in humans.
Since circadian patterns of food intake and body temperature constituteclock-controlled output systems, it is conceivable that their alteration in the transgenic mice stems from the higher amplitude of clock gene expression in the periphery, and possibly also in the central biological clock in the SCN.
In college, he pleaded no contest to two misdemeanor assault charges stemming from altercations with a neighbor and an ex-girlfriend.
