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Stemming from studies performed in mouse and cell lines, WSTF has been implicated as a key contributor to many of the phenotypes seen in WBS patients, despite the number of other genes that are also deficient [ 16, 35, 36].
Conveniently, histone modifications and the necessary 'machinery' for these processes has been very well studied in Drosophila, with much of the original evidence stemming from studies in this organism.
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The evidence primarily stems from studies based on questionnaires about sleep quality.
Mitchell, the movement's founder, told me that debriefing has been "distorted and misapplied" by some private companies, and noted that some negative findings stem from studies of these unorthodox variants.
The drug, called rimonabant, stems from studies of the so-called "endocannabinoid" biological pathway that is involved in giving marijuana smokers the "munchies".
An indirect support to this hypothesis stems from studies of MDTN in humans: MDTN lesions were associated with disinhibited or exaggerated responses to objects and environmental cues61 and alterations in time sense62,63.
But the urgency to reach teen-agers for prevention efforts stems from studies that have also found that people who have not started smoking by age 21 are unlikely to ever smoke.
This notion stems from studies reporting dysbiosis in mice lacking these inflammasome components when compared with non-littermate wild-type animals.
These results stem from studies among urban older people with close access to shops and services.
Indication that mTOR signaling is involved in oncogenic transformation stemmed from studies of Akt mutants with kinase activity but failed to phosphorylate p70S6 kinase and 4EBP1.
The following observations stem from studies on the developmental and reproductive toxicity of other PFCs: The toxic effects of N-Et-FOSE are similar to those of PFOS.
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