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A mouse knock-in model of the exon7/8 CLN3/battenin deletion reveals defects in the autophagy pathway, stemming from defects in autophagosome maturation (Cao et al., 2006).
DC is a rare genetic disorder stemming from a defect in telomere maintenance.
Clearly, α is in inverse relation with the PL yield, thus supporting the interpretation of the PL superlinarity as stemming from defect-related effects.
Another group of hereditary cancers comprises those that stem from inherited defects in DNA repair mechanisms.
The Jacksons, who are free on bail while they face charges of neglect, have claimed that the boys' scrawny bodies and brittle health stemmed from birth defects and eating disorders.
This disease has a well-established molecular link, which stems from defects or mutations in either of two genes TSC1 or TSC2 that cause uncontrolled cell growth.
The major difficulty stems from the network model which consists of highly nonlinear coupled equations.
DMD, which mainly affects boys, stems from defects in the gene coding for dystrophin, a protein that helps strengthen and protect muscle fibers.
Several human brain diseases have been proposed to stem from defects in asymmetric cell division and spindle orientation [ 7].
It appears that the pathogenesis of neurodegeneration in both type II GD and in PD stems from defects in proteostasis.
Further, aneuploidy rates are higher in oocytes and embryos from women with advanced maternal age (AMA) [ 4] which probably stems from meiotic recombination defects exacerbated by age [ 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com