It is widely acknowledged that chloride channel myotonia develops because the low chloride conductance in myotonia congenita patients cannot counterbalance the depolarization stemming from K+ accumulation in T-tubules (Adrian and Bryant, 1974; Cannon, 2001; Clausen, 2013).
Professor emeritus Alan Hallsworth Waterlooville, Hampshire One of the nicer ironies stemming from the grotesque accumulation of wealth that so concerns both Aditya Chakrabortty and Oxfam is that such accumulation is destroying the market economies that gave rise to it.
The other pathway stems from SA accumulation and signals through NPR1.
The decrease in FXN stems from an accumulation of GAA triplet repeats in the first intron of the gene through inheritance (9– 11).
Moreover, widows' vulnerability especially during the early stages of their widowhood— stems from an accumulation of challenges: limited resources, high levels of restrictions and responsibilities, and a lack of entitlements.
Indeed, a major limitation of hiPSC research stems from the accumulation of mutations in rapidly cycling cultured cells, such as hiPSCs and human ESCs (Baker et al., 2007; Mayshar et al., 2010).
However, this interpretation is complicated by the fact that some of the effects on OL survival arising from gene mutations stem from the accumulation of misfolded PLP product in the ER (Gow et al., 1998; Dhaunchak and Nave, 2007); thus multiple factors may contribute to reduced OL survival in mice harbouring mutations in the PLP gene.
Recent evidence in Dahl et al. (2009) suggests that single women induced to enter the labor market because of the EITC had higher subsequent earnings growth, possibly via increased human capital accumulation stemming from the positive employment effects of the EITC, although this study is based on considerably earlier data only from federal expansions of the EITC in the early 1990s.
Although the pathogenesis of sarcopenia is complex, ROS accumulation stemming from mitochondrial dysfunction plays a key role in this process.
Regardless of the tissue, the loss of Mfn2 leads to total atrophy and cell death, stemming from a systemic loss of mtDNA, accumulation of mtDNA mutations and metabolic incompetence.
There are several possible explanations, stemming from different viewpoints, as to why DAG accumulation leads to IR.
