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DC is a rare genetic disorder stemming from a defect in telomere maintenance.
We have previously shown that intracellular signaling from Clecsf8 can trigger particle phagocytosis (Graham et al., 2012; Miyake et al., 2013), and therefore examined the possibility that the phenotype of the Clecsf8−/− mice was stemming from a defect in mycobacterial uptake and clearance by leukocytes.
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Pre-eclampsia stems from a defect in early trophoblast invasion which may be sufficient to anchor the conceptus but is insufficient to fully convert the spiral arteries into low-resistance channels [8] [10].
We hypothesized that the diminished numbers of circulating platelets might stem from a defect in the development of MKs.
This suggests that the dNTP imbalance that we observe, as a function of vitality, could stem from a defect in cytosolic, as opposed to mitochondrial, dNTP pathways.
Despite this, poor lactate clearance appears to have prognostic value in normolactatemic and hyperlactatemic patients [ 14, 15] and may stem from a defect in lactate utilization rather than lactate overproduction.
This diabetes-mediated decrease in HIF-1α protein expression could stem from a defect in phosphorylated Akt (pAkt -mTOR-dependent signaling because this pAkt -mTOR-dependentwn to stimulate HIF-1 translation in respAkt -mTOR-dependentrowth factorsignalingskolin (Sengupta et al., 2010; Van de Velde et al., 2011).
Previous studies of indistinct cortical lamination and supernumerary neurons in both the molecular layer and white matter clearly indicate the presence of mild malformations stemming from a defect during corticogenesis.
Sudden cardiac arrest in a young person usually stems from a structural defect in the heart or a problem with its electrical circuitry.
Both diseases stem from a defective protein.
A mouse knock-in model of the exon7/8 CLN3/battenin deletion reveals defects in the autophagy pathway, stemming from defects in autophagosome maturation (Cao et al., 2006).
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