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But following aging or damage-induced reductions in stem pool fitness, together with damage or degradation of the niche, oncogenic events that improve fitness should provide selective advantages, leading to expansion of the oncogenic clone over time (bottom).
Similar(59)
MRT of stem pools is equivalent to rotation length.
Rodents have a small stem cell pool and a relatively larger pool of transit-amplifying progenitors, whereas rhesus testes appear to have a larger stem cell pool with a relatively smaller transit-amplifying progenitor compartment.
Relative to the respective stem cell pools, the progenitor pool appears much smaller in adult macaques than in rodents.
The tumor microenvironment can significantly contribute to stemness by activating or expanding the stem cell pool.
Indeed, the above scaling is consistent with the interpretation of the bone marrow as a heterogeneous microenvironment in which the active stem cell pool is distributed in surface niches [31], whereas the quiescent stem cell pool might presumably occupy the bulk of the bone marrow, in accord with the prevailing view of the stem cell pool as metaphorically compartmentalized [22].
In what regards the hematopoietic stem cell pool, there is experimental evidence that the size of the hematopoietic stem cell pool is conserved in mammals.
citizens to enter the STEM talent pool … under tailored circumstances".
Previous studies suggest that the stem cell pool decreases with age.
Hair follicle harbors a rich stem cell pool with mesenchymal lineage differentiation potential.
We assessed whether the tumor suppressor and mediator of cell contact inhibition Nf2/merlin plays a role in governing the hematopoietic stem cell pool by stem cell-autonomous or niche-determined processes.
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