In spite of the large number of reports on the beneficial effects of intracerebral stem cells injection in experimental stroke, very few studies demonstrated the effectiveness of the systemic intravenous delivery approach.
Differentiated muscle masses stained positively for alpha smooth muscle actin and myosin heavy chain at the muscle-derived stem cells injection sites.
No significant differences were observed with the control group, in which the rotator cuff repair was not followed by stem cells injection.
In the muscle-derived stem cells injection group, contraction amplitude was higher than in the cryoinjured group but not significantly (20.5 ± 21.3 vs. 17.3 ± 3.4 g per gram tissue, with acetylcholine (10−4 mol/l); 31 ± 14.2 vs. 18.4 ± 7.9 g per gram tissue, with KCl (10−4 mol/l)).
A total of 9 mice, including 3 control BALB/Cmice, 3 5-month-old mdx mice without stem cell injections and 3 mdx mice injected with stem cells, were used.
Stem cell injections will be given within two weeks of the injury.
In 2015, a 78-year-old woman visited ophthalmologist Thomas Albini after she received stem cell injections made from her belly fat from a Miami clinic.
At least four cases have been reported in medical journals of patients going blind or suffering severe vision impairment from stem cell injections.
