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This research provides a powerful method for mass-producing chitosan/graphene oxide hybrid microspheres for 3D stem cells expansion.
These T-IhNSC line provides a versatile model for the elucidation of the mechanisms involved in human neural stem cells expansion and for development of high throughput assays for both basic and translational research on human neural cell development.
In mice, BMI1 is necessary for bronchioloalveolar stem cells expansion [ 35].
Bovine-derived UC-WJ cells, collected individually from 5 different umbilical cords sources, were successfully cultured under serum-free conditions and were capable to support 60 consecutive passages using commercial Stemline® mesenchymal stem cells expansion medium.
There is also the intriguing possibility that the novel RANK variants, identified in this study, and especially TNFRSF11A_Δ7,8,9 have roles in the regulation of mammary stem cell and tumor-initiating cell (mammary cancer stem cells) expansion and renewal capacity, through the NF-kB machinery [ 40, 41].
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First, optimization of the stem cell expansion process is discussed.
Extended Data Fig. 9 Hemidesmosome-mediated lateral stem cell expansion facilitates skin wound healing.
Walasek, M. A., van Os, R. & de Haan, G. Hematopoietic stem cell expansion: challenges and opportunities.
Pineault, N. & Abu-Khader, A. Advances in umbilical cord blood stem cell expansion and clinical translation.
However, clinical translation hinges on the availability of effective stem cell expansion.
Liu, M. et al. The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
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