Sentence examples for stem cell turnover from inspiring English sources

Although LIF maintains neural stem cell turnover observed in vivo, exogenous LIF promotes gliogenesis alongside enhanced neurosphere production in vitro [ 27].

Furthermore increased Notch-1 expression was accompanied by an upregulation of CD135 which as previously discussed, is also important for stem cell turnover.

In disease states with reduced stem cell replicative reserve, substantially increased stem cell turnover or in the absence of telomerase activity short telomeres accumulate in hematopoietic stem cells [ 17].

As such, individual stem cell turnover at any given point would be minimal and the upregulation of telomerase activity in stem cells could be minimal, preventing the generation of overly long telomeres (Collins and Mitchell, 2002).

The DNM rate for SNV in the paternal germline is about four times greater than that in the maternal germline; it increases linearly by about two DNMs per year in line with spermatogonial stem cell turnover after puberty [ 7].

Stem-cell turnover means, for example, that tumours of the large intestine are commoner than those of the small one, while basal-cell carcinomas in the skin are commoner than melanomas.None of this, though, is reason for fatalism.

Therefore, crypts are more physically defined by niches that survive a lifetime rather than their stem cells that turnover.

Conversely stem cells that turnover slowly and thus divide infrequently generate long lived differentiated cells; a trait arguably favourable within adult tissues [ 8, 77].

The general correlation between stem cell number and epithelium turnover cycle in zebrafish is shown in Figure 4A.

Therefore, faced with a constant demand for cell turnover, stem cells may divide continually to generate a continual supply of differentiating cells that can deal rapidly with the daily demand of the tissue.

During normal tissue turnover new stem cell division progeny replace older differentiated cells.