First, optimization of the stem cell expansion process is discussed.
However, clinical translation hinges on the availability of effective stem cell expansion.
Additionally, we also discuss about various strategies that have been used in stem cell expansion.
Scarce endogenous mouse p63+/Krt5+ distal airway stem cell expansion was observed in damaged lung parenchyma as reported previously (Vaughan et al., 2015) (Fig. S5D).
Taken together, our hybrid-spheroids can be an ideal approach for stem cell expansion and serve as a potential carrier for bone regeneration.
The hybrid microspheres can support long-time stem cell expansion because of their good mechanical strength, controllable degradability, and low expansion rate when soaked in media.
Stem cell expansion has been limited due to the use of xenogenic factors in the culture system, batch-to-batch variation, and processes that do not readily lend themselves to scale-up.
Thus, although YAP/TAZ depletion has the potential to inhibit cancer stem cell expansion in a clinical setting[97], it is very likely that YAP/TAZ inhibition would also negatively affect essential stem cell pools in non-cancerous tissues.
In summary, increased YAP/TAZ activities are associated with stem cell expansion that is coupled with inhibition of differentiation, while reduction of YAP/TAZ activities results in the opposite effect.
In breast cancer, fibroblast-derived POSTN is crucial for breast cancer stem cell expansion during metastatic colonization in lung (Malanchi et al., 2012; Wang and Ouyang, 2012), which is very different from the function of GSC-derived POSTN in GBMs.
Dedicated to facilitating the development of cellular therapies here, SRC will explore areas such as stem cell biology, protein chemistry, stem cell markers, and growth factors in conjunction with ViaCell's patented Selective Amplification stem cell expansion technology.
