Sentence examples for stem cell doses from inspiring English sources

Several risk factors for graft failure have been suggested: transplantation of inadequate stem cell doses, use of human leukocyte antigen (HLA -mismatched donors or cord blood units, viral infections sucHLA -mismatchedvirus (CMV) andonorsn herpesvirus 6 (HHV-6), use or a non-myeloablative or reducordintensity conditioning regimen, and presence of donor-specific HLA antiblood

The AlphaSTEM tissue stem cell counting technology has many exciting applications, including determining the number of stem cells in experimental samples, determining the stem cell dose for transplantation treatments, identifying agents that can improve the vitality of transplanted tissue stem cells, and identifying agents that are toxic to tissue stem cells.

These data have prompted some to propose limiting both vector copy number as well as transduced stem cell dose to reduce the risk of insertional mutagenesis [10].

However, limiting numbers of gene marked LT-HSCs could paradoxically increase the risk of clonal dominance as such dominance appears more likely in the context of limited stem cell dose [26].

The target stem cell dose was 5 × 10 CD34+cells/kg.

In fact, many series have shown that above an optimum stem cell dose (approximately 8 10 × 10 cells/kg) the probability of mortality actually increases with increasing stem cell dose[ 33– 33].

Human data from our group and others suggests that the stem cell dose is not linearly related to survival.

Meluzín et al. [ 15] carried out the first clinical study to investigate the relationship between transplanted stem cell dose and treatment outcome in 2006.

It has been suggested that NK cell alloreactivity is associated with better outcome after allo SCT when a high stem cell dose, extensive T-cell depletion and ATG are used.

Given this fact that (above an optimum level) increased stem cell dose actually decreases survival, one cannot simply assume that the decreased stem cell homing seen following TBI will necessarily diminish survival.

The outcome of umbilical cord blood transplantation (UCBT) is compromised by low hematopoietic stem cell (HSC) doses leading to prolonged time to engraftment, delayed immunological reconstitution and late memory T-cell skewing.