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Peripheral blood stem cell collections obtained from 171 patients were analysed.
Adequate stem cell collections were also possible in 9/11 patients in whom it were attempted, suggesting that deferring high-dose chemotherapy for patients who relapsed after GAMEC was practical.
G-CSF administered to induce stem cell mobilization caused an increase in the number of MDSC in the peripheral blood of patients with MM and a concentration of these immune-suppressive cells in peripheral blood stem cell collections [ 94, 95].
We used stem cell collections of 4 million CD34 cells/kg, 8 million CD34 cells/kg and 12 cellscells million/kg as ideal goals for single, two or three transplants respectively as had been our practice during this study period.
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The stem cell collection, instead of taking three days, they probably had enough in one day.
Thirty-three (56%) of the patients received ATO-based therapy prior to stem cell collection.
Background: Central venous catheters (CVC) are frequently used for stem cell collection and recurrent therapeutic hemapheresis procedures for patients with poor peripheral venous access.
Using a prospective design, this investigation evaluated 94 patients at stem cell collection and again after high-dose therapy and transplantation.
Like Dr. Fisher, their treatment could start with the oral drug Revlimid or the intravenous treatment, Velcade, followed by stem cell collection.
Most donations - 90 per cent - now take place via peripheral blood stem cell collection, which is done at an outpatient appointment and is similar to donating blood.
Rituximab also demonstrated the ability to clear tumor cells from the circulation, allowing for an in vivo purging effect in the setting of peripheral stem cell collection and transplantation.
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