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Regenerative medicine and tissue engineering are searching for a novel stem cell based therapeutic strategy that will allow for efficient treatment or even potential replacement of damaged organs.
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Stem cell based therapy has been considered as the most promising therapeutic strategy for a range of debilitating diseases (Reynolds and Lamba, 2014).
The limitations of therapeutic options such as bone grafting and protein based therapy in the repair of massive bone defects shift interest to stem cell based regenerative medicine.
As cancer stem cells are more resistant to conventional therapeutic agents and play a major role in therapeutic failure and cancer recurrence, the development of novel agents that effectively kill cancer stem cells based on their unique metabolic properties will have major therapeutic implications.
The combination of stem cells with tissue engineering principles enables developing the stem cell-based therapeutic strategy for human diseases.
Human stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergone a renaissance as a major focus of investigation.
The results of our study imply that an imbalanced glucose metabolism can reduce the functioning ability of stem cells in vivo both during ageing and during stem cell-based therapeutic interventions.
Elucidation of physical regulation of 3D cell adhesion and orientation may offer a novel approach in controlling cell growth and differentiation and could be useful for stem cell-based therapeutic application and engineering tissue constructs.
These findings are of particular interest for modulation of the cellular biomechanics to control hMSCs' activities and fate in tissue engineering, regenerative medicine, and other stem cell-based therapeutic applications.
Thus, delivery of the NO-releasing microsphers to induce differentiation of stem cells within this three dimensional system may be one of possible strategies to direct differentiation of a stem cell-based therapeutic agent toward a specific lineage.
Results suggest that stem cell-based therapeutic modalities have the potential to decrease fatty infiltration after cuff repair, offer improvement in tendon-to-bone healing, increase generation of collagen I and improve the tendon's mechanical properties.
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