Sentence examples for steer cells from inspiring English sources

When subjected to external gradients of guidance cues, local flicker gradients are created de novo in the leading edge, which steer cells to turn in new directions as defined by the asymmetry of the flicker activity, apparently by a stochastic decision-making mechanism.

Gene methylation governs cell differentiation, and other aberrancies which can be key changes that steer cells towards a malignant phenotype.

These theoretical concepts provide the tools for rational design of gene network manipulations to steer cell fates for regenerative medicine instead of using trial-and-errors approaches.

The main technological aspects of additive manufacturing as a biofabrication approach to developing tissue-engineered constructs are first outlined by presenting and discussing different strategies involving the processing of cell-laden materials or the fabrication of scaffolds able to steer cell behavior through structural stimuli.

The dependency of the persistence on the type of ordered patterns suggests that key proteins related to the pattern regulate the location of F-actin accumulation and then steer cell movement.

Surprisingly, activation of this canonical survival pathway by hCNT1 steered cells toward death, although Erk inhibition partially inhibited cell death only in NP-9 cells; in NP-29 cells, in which Erk inhibition provoked an increase in Akt Ser473 phosphorylation, it had no such effect.

The mitosis was vigorous with high frequency of divisional cells and their quick turnover presumably steered cell proliferations.

Pauwels postulated that dilatational, volume changing stresses (tension, compression) steer stem cells toward chondrogenic lineages and that deviatoric, shape changing stresses (shear) steer stem cells toward ligamentous and tendonous lineages [25].

Whereas biochemical cues that steer stem cells toward osteogenic, myogenic, and chondrogenic [13] [20] lineages have been described in detail, more recent studies point toward a crucial role for biophysical signals in cell lineage determination [21] [25].

The identification of specific cues that steer stem cells from their niche and increase the efficiency of their engraftment to diseased tissues might help to identify tools to improve stem cell therapies.

These observations raise the intriguing possibility that abnormal changes in splicing can steer cancer cells towards malignant progression through a partial EMT, without the need for canonical transcriptional reprogramming.